I. 学術論文（56報、うち筆頭著者論文：43報）

 

1. Nakanishi A., Imajoh-Ohmi S., Fujinawa T., Kikuchi H. and Kanegasaki S.: Direct evidence for interaction between COOH-terminal regions of cytochrome b558 subunits and cytosolic 47-kDa protein during activation of an O₂^--generating system in neutrophils.

J. Biol. Chem., 267: 19072-19074 (1992)

 

2. Kikuchi H., Imajoh-Ohmi S. and Kanegasaki S.: Novel antibodies specific for proteolyzed forms of protein kinase C: Production of anti-peptide antibodies available for in situ analysis of intracellular limited proteolysis.

Biochim. Biophys. Acta -Protein Mol. Enzymol., 1162: 171-176 (1993)

 

3. Kikuchi H., Fujinawa T., Kuribayashi F., Nakanishi A., Imajoh-Ohmi S., Goto M. and Kanegasaki S.: Induction of essential components of the superoxide generating system in human monoblastic leukemia U937 cells.

J. Biochem., 116: 742-746 (1994)

 

4. Kikuchi H., Sugiyama S. and Imajoh-Ohmi S.: A novel anti-apoptosis serum factor that downregulates Fas-mediated apoptosis.

J. Biochem., 117: 936-939 (1995)

 

5. Kikuchi H. and Imajoh-Ohmi S.: Activation and possible involvement of calpain, a calcium-activated cysteine protease, in down-regulation of apoptosis of human monoblast U937 cells.

Cell Death Differ., 2: 195-199 (1995)

 

6. Imajoh-Ohmi S., Kawaguchi T., Sugiyama S., Tanaka K., Omura S. and Kikuchi H.: Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells.

Biochem. Biophys. Res. Commun., 217: 1070-1077 (1995) ＊2015年ノーベル医学生理学賞受賞者、大村智博士との共同研究です。

 

7. Kikuchi H. and Imajoh-Ohmi S.: Antibodies specific for proteolyzed forms of protein kinase C α. Biochim. Biophys. Acta -Mol. Cell Res., 1269: 253-259 (1995)

 

8. Murakami A., Chida K., Suzuki Y., Kikuchi H., Imajoh-Ohmi S. and Kuroki T.: Absence of down-regulation and translocation of the η isoform of protein kinase C in normal human karatinocytes.

J. Invest. Dermatol., 106: 790-794 (1996)

 

9. Kuwahara K., Kawai T., Mitsuyoshi S., Matsuo Y., Kikuchi H., Imajoh-Ohmi S., Hashimoto E., Inui S., Cooper M.D. and Sakaguchi N.: Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase.

Int. Immunol., 8: 1273-1285 (1996)

 

10. Kikuchi H., Iizuka R., Sugiyama S., Gon G., Mori H., Arai M., Mizumoto K. and Imajoh-Ohmi S.: Monocytic differentiation modulates apoptotic response to cytotoxic anti-Fas antibody and tumor necrosis factor α in human monoblast U937 cells.

J. Leukoc. Biol., 60: 778-783 (1996)

 

11. Kikuchi H., Hirose S., Toki S., Akama K. and Takaiwa F.: Molecular characterization of a gene for alanine aminotransferase from rice (Oryza sativa).

Plant Mol. Biol., 39: 149-159 (1999)

 

12. Takami Y., Kikuchi H. and Nakayama T.: Chicken histone deacetylase-2 controls the amount of the IgM H-chain at the steps of both transcription of its gene and alternative processing of its pre-mRNA in the DT40 cell line.

J. Biol. Chem., 274: 23977-23990 (1999)

 

13. Kato M., Nonaka T., Maki M., Kikuchi H. and Imajoh-Ohmi S.: Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells.

J. Biochem., 127: 297-305 (2000)

 

14. Kikuchi H., Takami Y. and Nakayama T.: GCN5: a supervisor in all-inclusive control of vertebrate cell cycle progression through transcription regulation of various cell cycle-related genes.

Gene, 347: 83-97 (2005)

 

15. Ahmad A., Kikuchi H., Takami Y. and Nakayama T.: Different roles of N-terminal and C-terminal halves of HIRA in transcription regulation of cell cycle-related genes that contribute to control of vertebrate cell growth.

J. Biol. Chem., 280: 32090-32100 (2005)

 

16. Nakayama M., Suzuki S., Yamamoto-Nagamatsu N., Barman H. K., Kikuchi H., Takami Y., Toyonaga K., Yamashita K. and Nakayama T.: HDAC2 controls IgM H- and L-chain gene expressions via EBF1, Pax5, Ikaros, Aiolos and E2A gene expression.

Genes Cells, 12: 359-373 (2007)

 

17. Kikuchi H. and Nakayama T.: GCN5 and BCR signalling collaborate to induce pre-mature B cell apoptosis through depletion of ICAD and IAP2 and activation of caspase activities.

Gene, 419: 48-55 (2008)

 

18. Toyonaga K., Kikuchi H. (co-first author), Yamashita K., Nakayama M., Chijiiwa K. and Nakayama T.: E2A participates in a fine control of pre-mature B-cell apoptosis mediated by B-cell receptor signaling via transcriptional regulation of survivin, IAP2 and caspase-8 genes.

FEBS J., 276: 1418-1428 (2009)

 

19. Kikuchi H., Yamashita K., Nakayama M., Toyonaga K., Tsuneyoshi I., Takasaki M. and Nakayama T.: Lacking of Aiolos accelerates pre-mature B cell apoptosis mediated by BCR signaling through elevation in cytochrome c release.

Biochim. Biophys. Acta - Mol. Cell Res., 1793: 1304-1314 (2009)

 

20. Kikuchi H., Kuribayashi F., Kiwaki N. and Nakayama T.: Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in U937 cells. Biochem. Biophys. Res. Commun., 395: 61-65 (2010)

 

21. Kikuchi H., Kuribayashi F., Takami Y., Imajoh-Ohmi S. and Nakayama T.: GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.

Biochem. Biophys. Res. Commun., 405: 657-661 (2011)

 

22. Kikuchi H., Kuribayashi F., Kiwaki N., Takami Y. and Nakayama T.: GCN5 regulates the superoxide-generating system in leukocytes via controlling gp91-phox gene expression.

J. Immunol., 186: 3015-3022 (2011)

 

23. Kikuchi H., Nakayama M., Takami Y., Kuribayashi F. and Nakayama T.: Possible involvement of Helios in controlling the immature B cell functions via transcriptional regulation of protein kinase Cs. Results Immunol., 1: 88-94 (2011)

 

24. Kikuchi H., Nakayama M., Takami Y., Kuribayashi F. and Nakayama T.: EBF1 acts as a powerful repressor of Blimp-1 gene expression in immature B cells.

Biochem. Biophys. Res. Commun., 422: 780-785 (2012)

 

25. Kikuchi H., Kuribayashi F., Imajoh-Ohmi S., Nishitoh H., Takami Y. and Nakayama T.: GCN5 protects vertebrate cells against UV-irradiation via controlling gene expression of DNA polymerase η.

J. Biol. Chem., 287: 39842-39849 (2012)

 

26. Kikuchi H., Kuribayashi F. and Imajoh-Ohmi S.: Down-regulation of Fas-mediated apoptosis by plasma transglutaminase factor XIII that catalyzes fetal-specific cross-link of the Fas molecule. Biochem. Biophys. Res. Commun., 443: 13-17 (2014)

 

27. Kikuchi H., Nakayama M., Kuribayashi F., Imajoh-Ohmi S., Nishitoh H., Takami Y. and Nakayama T.: GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells.

J. Leukoc. Biol., 95: 399-404 (2014) ＊掲載号のHighlighted Articleに選出されました。

 

28. Kikuchi H., Nakayama M., Kuribayashi F., Imajoh-Ohmi S., Nishitoh H., Takami Y. and Nakayama T.: Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells. FEBS Lett., 588: 1739-1742 (2014)

 

29. Kikuchi H., Nakayama M., Kuribayashi F., Imajoh-Ohmi S., Nishitoh H., Takami Y. and Nakayama T.: GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells.

Gene, 544: 19-24 (2014)

 

30. Kikuchi H., Nakayama M., Kawai C., Kuribayashi F., Mimuro H., Imajoh-Ohmi S., Nishitoh H., Takami Y. and Nakayama T.: Histone acetyltransferase p300/CBP-associated factor is an effective suppressor of secretory immunoglobulin synthesis in immature B cells.

Microbiol. Immunol., 59: 243-247 (2015)

 

31. Kikuchi H., Kuribayashi F., Mimuro H., Imajoh-Ohmi S., Nakayama M., Takami Y., Nishitoh H. and Nakayama T.: Lack of GCN5 remarkably enhances the resistance against prolonged endoplasmic reticulum stress-induced apoptosis through up-regulation of Bcl-2 gene expression.

Biochem. Biophys. Res. Commun., 463: 870-875 (2015)

 

32. Kikuchi H., Nakayama M., Kuribayashi F., Mimuro H., Imajoh-Ohmi S., Nishitoh H., Takami Y. and Nakayama T.: Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells.

Microbiol. Immunol., 59: 426-431 (2015)

 

33. Kikuchi H., Nakayama M., Kuribayashi F., Mimuro H., Imajoh-Ohmi S., Nishitoh H. and Nakayama T.: Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells.

Biochem. Biophys. Res. Commun., 467: 509-513 (2015)

 

34. Kikuchi H., Kuribayashi F., Mimuro H. and Imajoh-Ohmi S.: GCN5-deficiency remarkably enhances the sensitivity of B cells in response to 4-nitroquinoline 1-oxide.

Fumdam. Toxicol. Sci., 3: 137-142 (2016)

 

35. Kikuchi H., Mimuro H. and Kuribayashi F.: Resveratrol strongly enhances the retinoic acid-induced superoxide generating activity via up-regulation of gp91-phox gene expression in U937 cells. 

Biochem. Biophys. Res. Commun., 495: 1195-1200 (2018)

 

36. Kikuchi H.: Enzymatic preparation of O-β-D-galactopyranosyl-(1,6)-2-amino-2-deoxy-D-glucosaminic acid by transgalactosylation catalyzed by Aspergillus oryzae β-D-galactosidase.

J. Assoc. Food Sci. Edu. Japan, 9: 9-12 (2018)

 

37. Kikuchi H., Kuribayashi F. and Madhyastha H.: Positions and numbers of hydroxyl groups in hydroxychalcone derivatives are involved in cytotoxicity against human monoblastic U937 cells.

Fumdam. Toxicol. Sci., 5: 149-152 (2018)

 

38. Kikuchi H., Kuribayashi F., Nakayama M. and Nakayama T.: Gene targeting techniques reveal that histone acetyltransferase GCN5 has various inherent physiological functions in chicken DT40 cells. (review article)

Curr. Topics Biochem. Res., 19: 13-23 (2018) 

 

39. Kikuchi H., Mimuro H., Madhyastha H. and Kuribayashi F.: Chalcone skeleton promotes transcription of gp91-phox gene but inhibits expression of gp91-phox protein, and hydroxyl groups in hydroxychalcones participate in the stable expression of gp91-phox protein.

Microbiol. Immunol., 63: 438-443 (2019)

 

40. Akiyoshi S., Kikuchi H., Kuribayashi F., Madhyastha H. and Minami H.: Sulforaphane displays the growth inhibition, cytotoxicity and enhancement of retinoic acid-induced superoxide-generating activity in human monoblastic U937 cells.

Fumdam. Toxicol. Sci., 6: 319-325 (2019) 

 

41. Kikuchi H., Kuribayashi F., Nakayama M. and Nakayama T.: Functions of B cell development-related transcription factors systematically revealed in immature B cells by gene targeting techniques using chicken DT40 cells. (review article)

Curr. Topics Biochem. Res., 20: 43-52 (2019) 

 

42. Akiyoshi S., Kikuchi H. and Minami H.: Sulforaphane shows remarkable growth inhibition and cytotoxicity against several human leukemia cell lines.

J. Assoc. Food Sci. Edu. Japan, 11: 1-7 (2020)

 

43. Tsuruta C., Mimura A., Harata K. and Kikuchi H.: Sulforaphane shows growth inhibitory effects against Escherichia coli and Bacillus subtilis via reactive oxygen species production.

J. Assoc. Food Sci. Edu. Japan, 11: 9-12 (2020)

 

44. Kikuchi H., Harata K., Kawai C., Madhyastha H., Yamauchi A. and Kuribayashi F.: Retinoic acid dramatically enhances cytotoxicity of equal against human monoblastic U937 cells, but not against human peripheral neutrophils.

Fumdam. Toxicol. Sci., 7: 201-206 (2020) 

 

45. Shibata A., Harata K., Moriguchi Y., Kanegawa R., Nagahira A., Shigematsu M., Takamura Y., Watanabe H., Sagara T., Madhyastha, H. and Kikuchi H.: Production and evaluation of the authentic milk bread using a lactose-utilizing yeast, Kluyveromyces marxianus.

Curr. Top. Biotech., 11: 31-36 (2020)

 

46. Kikuchi H., Harata K., Madhyastha H. and Kuribayashi F.: Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells.

Biochem. Biophys. Rep., 25: 100891 (2021)

 

47. Kikuchi H., Nakagawa Y., Hirayama Y. and Harata K.: Transcriptional profiles of histone acetyltransferases in human monoblast U937 cells treated with all-trans retinoic acid or 1α, 25-dihydroxyvitamin D3.

J. Assoc. Food Sci. Edu. Japan, 12: 19-24 (2021)

 

48. Shibata A., Ichihara S., Kubota M., Sakata A., Shibata A., Moriguchi Y., Harata K., Sagara T. and Kikuchi H.: Possibility for nutritional improvement of the "authentic" milk bread by increasing the amount of milk added.

J. Assoc. Food Sci. Edu. Japan, 12: 25-30 (2021)

 

49. Kikuchi H., Harata K., Akiyoshi S., Madhyastha H. and Kuribayashi F.: 3', 4'-Dihydroxyflavone enhances all-trans retinoic acid-induced superoxide-generating activity through up-regulating transcription of gp91-phox in human monoblastic U937 cells, as opposed to flavone and other hydroxyflavone derivatives.

Fundom. Toxicol. Sci., 8: 53-59 (2021) 

 

50. Kikuchi H.: Pheophorbide-a acts as a photodynamic DNA-damaging reagent that causes remarkable increase in 8-hydroxydeoxyguanosine in cellular DNA.

J. Assoc. Food Sci. Edu. Japan, 13: 15-19 (2022)

 

51. Kikuchi H., Harata K., Akiyoshi S., Sagara T., Madhyastha H. and Kuribayashi F.: Potential role of green tea amino acid L-theanine in the activation of innate immune response by enhancing expression of cytochrome b558 responsible for the reactive oxygen species-generating ability of leukocytes.

Microbiol. Immunol., 66: 342-349 (2022)

 

52. Kikuchi H., Harata K., Akiyoshi S., Sagara T., Madhyastha H., Mimuro H. and Kuribayashi F.: Bifunctional activity of tangeretin (5,6,7,8,4'-pentamethoxyflavone) in suppression of cell growth and gene expression of the superoxide-generating system-related proteins in U937 cells.

Fundom. Toxicol. Sci., 9: 151-157 (2022) 

 

53. Kikuchi H. : Production of N-acetyllactosamine using transgalactosylation activity of Aspergillus oryzae in Czapek-Dox liquid medium.

J. Assoc. Food Sci. Edu. Japan, 14: 9-14 (2023)

 

54. Kikuchi H., Harata K., Akiyoshi S., Sagara T., Madhyastha H., Mimuro H. and Kuribayashi F.: Coffee diterpenes, cafestol and kahweol, display cytotoxicity and all-trans retinoic acid-induced superoxide-generating activity-enhancing ability in U937 cells.

Fundom. Toxicol. Sci., 10: 233-240 (2023) 

 

55. Kikuchi H., Fujita S., Harata K., Betto M., Moriguchi Y., Sanematsu F., Madhyastha H. and Sagara T.: Production and evaluation of a unique type of bread using as the only carbohydrate source for bread fermentation with the inulinase-producing yeast, Kluyveromyces marxianus.

Curr. Topics Biotech., 14: 13-18 (2023)

 

56. Kikuchi H., Harata K., Madhyastha H., Mimuro H. and Kuribayashi F.: Aristolochic acid C displays cytotoxic effect and remarkable enhancing effect on the all-trans retinoic acid-induced superoxide-generating ability in U937 cells.

Fundom. Toxicol. Sci., 11: 197-204 (2024) 

  

II. 著書

 

1. Kikuchi H., Barman H.K., Nakayama M., Takami Y. and Nakayama T.: Participation of histones, histone modifying enzymes and histone chaperones in vertebrate cell functions. Reviews and Protocols in DT40 Research: Subcellular Biochemistry 40. Buerstedde J. M. and Takeda S. (Eds.) Springer-Verlag, pp. 225-243 (2006)

 

2. Kikuchi H., Barman H. K., Nakayama M., Takami Y. and Nakayama T.: Studies on Epigenetic Control of B Cell Functions Using the DT40 Cell Line. Advances in Genetics Research, Volume 2. Urbano K. V. (Ed.) Nova Publisher, pp. 153-166 (2010)

 

 

III. 特許

 

1.  菊池秀彦、木脇直美、中山建男：レチノイン酸効果増強剤およびこれを用いたリンパ腫治療剤キット、並びに、活性酸素産生促進剤およびこれを用いた免疫賦活剤（特願2010-059734、特開2011-190228）

 

2. 菊池秀彦、相良剛史、原田香、柴田文：パン、パン生地およびパンの製造方法（特願2020-099640、特開2021-192600）

 

3. 菊池秀彦、相良剛史、實松史幸、原田香、藤田紗香：イヌリンを発酵させて製造されたパン、パン生地およびパンの製造法（特願2023-171728）

 

 

IV. 総説

 

1. 菊池秀彦、大海忍、金ヶ崎士朗：好中球の活性化機構.　細胞、26巻: 124-129 (1994)

 

2. 菊池秀彦、大海忍：アポトーシスでの細胞内プロテアーゼの機能—切断部位特異抗体を用いた解析.　細胞工学、15巻: 339-344 (1996)